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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAT1A All Species: 41.82
Human Site: S22 Identified Species: 61.33
UniProt: Q00266 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q00266 NP_000420.1 395 43648 S22 E G V F M F T S E S V G E G H
Chimpanzee Pan troglodytes XP_515585 413 45605 S22 E G T F L F T S E S V G E G H
Rhesus Macaque Macaca mulatta XP_001087977 396 43707 S23 E G A F M F T S E S V G E G H
Dog Lupus familis XP_851933 396 43499 S23 E G A F M F T S E S V G E G H
Cat Felis silvestris
Mouse Mus musculus Q91X83 396 43490 S23 E G A F M F T S E S V G E G H
Rat Rattus norvegicus P13444 397 43679 S23 E G A F M F T S E S V G E G H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_421512 396 43734 S23 E G A F M F T S E S V G E G H
Frog Xenopus laevis NP_001080175 396 43767 S23 E G S F L F T S E S V G E G H
Zebra Danio Brachydanio rerio NP_956165 390 43271 G21 M F T S E S V G E G H P D K I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P40320 408 44678 S33 G A T F L F T S E S V G E G H
Honey Bee Apis mellifera XP_623669 404 44652 S30 E G S F L F T S E S V G E G H
Nematode Worm Caenorhab. elegans P50305 404 44016 C22 E G H P D K M C D Q I S D A V
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa A9P822 392 43195 C20 E G H P D K L C D Q I S D A V
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LUT2 393 42777 C20 E G H P D K L C D Q I S D A I
Baker's Yeast Sacchar. cerevisiae P10659 382 41800 C21 E G H P D K I C D Q V S D A I
Red Bread Mold Neurospora crassa P48466 395 42967 S21 E G T F L F T S E S V G E G H
Conservation
Percent
Protein Identity: 100 80.1 98.2 95.9 N.A. 96.2 95.7 N.A. N.A. 90.9 84.8 82.2 N.A. 68.6 70.5 68.3 N.A.
Protein Similarity: 100 88.6 99.2 98.4 N.A. 98.4 98.4 N.A. N.A. 96.4 92.9 92.6 N.A. 85.5 86.3 83.1 N.A.
P-Site Identity: 100 86.6 93.3 93.3 N.A. 93.3 93.3 N.A. N.A. 93.3 86.6 6.6 N.A. 73.3 86.6 13.3 N.A.
P-Site Similarity: 100 93.3 93.3 93.3 N.A. 93.3 93.3 N.A. N.A. 93.3 93.3 13.3 N.A. 80 93.3 33.3 N.A.
Percent
Protein Identity: 61 N.A. N.A. 60.7 66.5 68.1
Protein Similarity: 75.9 N.A. N.A. 77.4 81.2 82.7
P-Site Identity: 13.3 N.A. N.A. 13.3 20 86.6
P-Site Similarity: 33.3 N.A. N.A. 33.3 33.3 93.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 32 0 0 0 0 0 0 0 0 0 0 25 0 % A
% Cys: 0 0 0 0 0 0 0 25 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 25 0 0 0 25 0 0 0 32 0 0 % D
% Glu: 88 0 0 0 7 0 0 0 75 0 0 0 69 0 0 % E
% Phe: 0 7 0 69 0 69 0 0 0 0 0 0 0 0 0 % F
% Gly: 7 88 0 0 0 0 0 7 0 7 0 69 0 69 0 % G
% His: 0 0 25 0 0 0 0 0 0 0 7 0 0 0 69 % H
% Ile: 0 0 0 0 0 0 7 0 0 0 19 0 0 0 19 % I
% Lys: 0 0 0 0 0 25 0 0 0 0 0 0 0 7 0 % K
% Leu: 0 0 0 0 32 0 13 0 0 0 0 0 0 0 0 % L
% Met: 7 0 0 0 38 0 7 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 25 0 0 0 0 0 0 0 7 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 25 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 13 7 0 7 0 69 0 69 0 25 0 0 0 % S
% Thr: 0 0 25 0 0 0 69 0 0 0 0 0 0 0 0 % T
% Val: 0 0 7 0 0 0 7 0 0 0 75 0 0 0 13 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _